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	<title>Pattern Recognition.</title>
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	<pubDate>Sun, 18 May 2008 08:42:49 +0000</pubDate>
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		<title>The Truth About Illegal Immigrants</title>
		<link>http://blog.maxmasnick.com/the-truth-about-illegal-immigrants</link>
		<comments>http://blog.maxmasnick.com/the-truth-about-illegal-immigrants#comments</comments>
		<pubDate>Sun, 18 May 2008 08:41:44 +0000</pubDate>
		<dc:creator>Max</dc:creator>
		
		<category><![CDATA[Opinion]]></category>

		<guid isPermaLink="false">http://blog.maxmasnick.com/the-truth-about-illegal-immigrants</guid>
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  According to immigration laws, there are more than 10 million[i] criminals living among us. They are considered criminals not because they have tried to hurt someone—in fact, most are only trying to feed their families and are actually important contributors to the economy. We call them illegal immigrants, and they are criminalized, stigmatized, [...]]]></description>
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  According to immigration laws, there are more than 10 million<a style="mso-endnote-id:edn" href="#_edn1" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[i]</span></span></a> criminals living among us. They are considered criminals not because they have tried to hurt someone—in fact, most are only trying to feed their families and are actually important contributors to the economy. We call them illegal immigrants, and they are criminalized, stigmatized, and subjected to substandard working and living conditions—even though our economy depends on the labor they provide.<a style="mso-endnote-id:edn" href="#_edn2" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[ii]</span></span></a> These injustices are at least partially the fault of policies that make it difficult for immigrants to work legally and do not offer sufficient protection to legal migrant workers. We must question whether these policies are fair to the immigrant workers we depend on and whether they best serve the American economy.
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  Illegal immigrants contribute to many sectors of the economy, but farms are especially dependent on their labor. Farmers admit that as many as 70 percent of the workers they hire are illegal.<a style="mso-endnote-id:edn" href="#_edn3" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iii]</span></span></a> When faced with tighter enforcement of immigration rules, some farmers have chosen to shut down rather than risk not being able to find workers to pick their crops—there are often not enough local and legal seasonal workers to get the job done.<a style="mso-endnote-id:edn" href="#_edn4" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iv]</span></span></a> And in addition to being crucial for farmers, farm labor from the migrant workforce is important for counter rising food prices<a style="mso-endnote-id: edn" href="#_edn5" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[v]</span></span></a> in our struggling economy.
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  Programs like the Federal H2-A program do allow some seasonal workers to enter the United States legally, but fail to address many of the problems faced by illegal immigrants. H2-A workers are guaranteed a minimum wage and a basic level of living conditions. However, their paychecks are at the mercy of the weather, and they do not have access to safety net programs like welfare and Social Security. The living conditions of some H2-A workers could be considered unacceptable, though the housing provided by farmers for their H2-A workers is theoretically subject to government oversight. And like many illegal immigrants, legal seasonal workers are often stigmatized and isolated from the communities surrounding them.<a style="mso-endnote-id:edn" href="#_edn6" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vi]</span></span></a> These shortcomings of the H2-A program must be addressed if migrant worker programs are to be fair to immigrants.
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  Illegal immigrants face the same problems as legal migrant workers, in addition to a slew of more formidable challenges. To begin with, they are not covered by minimum wage laws when paid under the table, leaving them with no protection from falling wages caused by the recent economic downturn.<a style="mso-endnote-id:edn" href="#_edn7" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[vii]</span></span></a> Those whose paychecks are above the table pay taxes without benefiting from public services: illegal immigrants are often reluctant to go to hospitals, send their children to schools, and report crimes to the police for fear of imprisonment or deportation.<a style="mso-endnote-id:edn" href="#_edn8" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[viii]</span></span></a> Others do not even make it to America—thousands of illegal immigrants have died attempting to cross the deadly desert along the United States-Mexico border.<a style="mso-endnote-id:edn" href="#_edn9" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ix]</span></span></a> Given the hardships faced by illegal immigrants, it is clear that current immigration policies fail to recognize the important role illegal immigrants play in our economy.
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  Even if it were possible, closing our borders is not an option. While it may be true that illegal immigrants and seasonal workers take some jobs from American citizens, it is clear that some sectors of the economy would cease to function without immigrant labor. Since we depend on immigrant workers for our economic wellbeing, it is our responsibility to offer them the same basic public services and workplace standards afforded to citizens—anything less is exploitation. Such reform is actually in our best interest: illegal immigrants are often perceived as stealing jobs from citizens by working for less than minimum wage or draining public service programs, and these problems could be ameliorated by making it easy for all immigrants to work legally and above the table.
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  The truth is that our current immigration policy is unfair to immigrants and to Americans. Immigrants come to the United States to provide for their families while contributing positively to our economy—yet we exploit them, call them criminals, and deny them basic workers’ rights. Americans are hurt when enforcement of immigration laws makes it difficult to find the workers they need to run their businesses, or when they are forced to compete for jobs with illegal immigrants who are paid under the table. It’s time to stop this senseless talk of closing our borders and enforcing immigration laws in their current form. Instead, immigration policy must change to reflect reality: immigrants are a crucial part of our economy and should be treated as such.
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<p class="MsoNormal" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn1" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[i]</span></span></a> Hoefer, Michael, Nancy Rytina, and Christopher Campbell. “Estimates of the Unauthorized Immigrant Population Residing in the United States: January 2005.” Office of Immigration Statistics Policy Directorate, Department of Homeland Security. 20 April 2008 &lt;http://www.dhs.gov/xlibrary/assets/statistics/publications/ILL_PE_2005.pdf&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn2" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ii]</span></span></a> Preston, Julia. “Farmers Call Crackdown on Illegal Workers Unfair.” <u>The New York Times</u>. 11 August 2007. 20 April 2008 &lt;http://www.nytimes.com/2007/08/11/us/11immig.htm&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn3" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iii]</span></span></a> See 2.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn4" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iv]</span></span></a> Vitello, Paul. “Immigration Issues End a Pennsylvania Grower’s Season.” <u>The New York Times</u>. 2 April 2008. 20 April 2008 &lt;http://www.nytimes.com/2008/04/02/us/politics/02penn.html&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn5" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[v]</span></span></a> Barta, Patrick. “Higher Food Prices May Be Here to Stay.” <u>The Wall Street Journal</u>. 14 April 2008: A2. 20 April 2008 &lt;http://online.wsj.com/article/SB120811953255811087.html&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn6" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vi]</span></span></a> <u>The Guestworker</u>. Cynthia Hill and Chalres Thompson. Video. Markay Media, 2006.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn7" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vii]</span></span></a> “Illegal Immigration&#8217;s Impact on the U.S. Economy.” National Public Radio. 26 August 2005. 20 August 2008 &lt;http://www.npr.org/templates/story/story.php?storyId=4817071&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;">“Employment Situation Summary.” Bureau of Labor Statistics, United States Department of Labor. 20 August 2008 &lt;http://stats.bls.gov/news.release/empsit.nr0.htm&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn8" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[viii]</span></span></a> McKinley, Jesse. “San Francisco Reaches Out to Immigrants.” <u>The New York Times</u>. 6 April 2008. 20 April 2008 &lt;http://www.nytimes.com/2008/04/06/us/06immig.html&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn9" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ix]</span></span></a> “Death on the Border.” <u>azstarnet.com</u>, the online version of the <u>The Arizona Daily Star</u>. 20 April 2008 &lt;http://regulus.azstarnet.com/borderdeaths/search.php&gt;.</p>
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		<title>A Cure for American’s Ailing Health Care System</title>
		<link>http://blog.maxmasnick.com/a-cure-for-american%e2%80%99s-ailing-health-care-system</link>
		<comments>http://blog.maxmasnick.com/a-cure-for-american%e2%80%99s-ailing-health-care-system#comments</comments>
		<pubDate>Sun, 18 May 2008 08:35:37 +0000</pubDate>
		<dc:creator>Max</dc:creator>
		
		<category><![CDATA[Opinion]]></category>

		<guid isPermaLink="false">http://blog.maxmasnick.com/a-cure-for-american%e2%80%99s-ailing-health-care-system</guid>
		<description><![CDATA[
The American health care system is sick. We hear pundits, the media, and the presidential candidates describe its symptoms—47 million Americans are uninsured[i] and an alarming 16% of our GDP is spent on health care[ii]—but these statistics miss the causes of its disease. The sky-high costs of care and insurance, the increasing prevalence of chronic [...]]]></description>
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<p class="MsoNormal" align="center" style="text-align: left;">The American health care system is sick. We hear pundits, the media, and the presidential candidates describe its symptoms—47 million Americans are uninsured<a style="mso-endnote-id:edn" href="#_edn1" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[i]</span></span></a> and an alarming 16% of our GDP is spent on health care<a style="mso-endnote-id: edn" href="#_edn2" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ii]</span></span></a>—but these statistics miss the causes of its disease. The sky-high costs of care and insurance, the increasing prevalence of chronic diseases like obesity, and many other failings of our health care system stem from a single underlying problem: we treat people after they become sick. The only way to cure America’s health care system is to stop merely reacting to disease, and instead take a preventive, prospective approach to health care.</p>
<p class="MsoNormal" align="center" style="text-align: left;">America’s obesity epidemic is a prime example of the failure of our reactionary health care system. In 2003, more than 30% of Americans were obese.<a style="mso-endnote-id:edn" href="#_edn3" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iii]</span></span></a> Obesity increases the risk of many serious diseases, including hypertension, heart disease, and diabetes.<a style="mso-endnote-id:edn" href="#_edn4" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[iv]</span></span></a> It is also often entirely preventable: the major causes of the obesity epidemic stem from social changes occurring over the last 40 years, namely decreased amounts of physical activity and higher caloric intake.<a style="mso-endnote-id:edn" href="#_edn5" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[v]</span></span></a> Yet the current health care system usually becomes involved only after an individual’s obesity leads to a serious medical condition.</p>
<p class="MsoNormal" align="center" style="text-align: left;">Chronic diseases like obesity account for almost 75% of America’s health care spending, and two-thirds of our health care dollars are spent caring for patients with five or more chronic conditions.<a style="mso-endnote-id:edn" href="#_edn6" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vi]</span></span></a> Americans have the right to see their health care dollars used as efficiently as possible, yet billions of dollars are spent each year treating these often-preventable conditions.<a style="mso-endnote-id:edn" href="#_edn7" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[vii]</span></span></a> If we reduce the prevalence of chronic disease, America will spend less on health care and be healthier.</p>
<p class="MsoNormal" align="center" style="text-align: left;">Preventing many of these chronic diseases is possible today with a novel approach to health care developed at Duke University.<a style="mso-endnote-id:edn" href="#_edn8" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[viii]</span></span></a> This approach, called <i style="mso-bidi-font-style:normal">prospective health care</i>, makes use of recent scientific and medical innovations to accurately predict each individual’s susceptibility to a variety of diseases. Doctors can use this information to create personalized health care plans designed to prevent disease entirely when possible, and at the very least treat disease early and effectively. Patients are able to take responsibility for their own health by following their tailor-made plan, with continuous support from the prospective health care system.</p>
<p class="MsoNormal" align="center" style="text-align: left;">If we have the ability to prevent chronic disease with prospective health care, we must ask why we aren’t doing it. One answer to this question is that our diseased health care system is designed only for reactive medicine. Even though disease prevention costs much less than treating serious illness,<a style="mso-endnote-id:edn" href="#_edn9" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[ix]</span></span></a> it is difficult or even impossible for doctors to charge insurers for preventative medicine. It is especially hard for doctors to be reimbursed for ordering cutting-edge medical tests or using other new technologies, even if they are the most effective option.<a style="mso-endnote-id:edn" href="#_edn10" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[x]</span></span></a> Our reimbursement system actually penalizes doctors who practice prospective health care: in addition to difficulties with billing insurers, these doctors will lose business down the road from their patients who would have otherwise become ill.</p>
<p class="MsoNormal" align="center" style="text-align: left;">Politicians are beginning to notice these problems. All three presidential candidates list various aspects of prospective health care as part of their health care platforms.<a style="mso-endnote-id:edn" href="#_edn11" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[xi]</span></span></a> Their plans also include elements of the substantial changes necessary to make prospective health care available on a national scale. These changes must begin with insurers and Medicaid/Medicare: patients’ health care budgets are already exhausted from paying into the current system, so it is essential insurers and government programs begin to both encourage and pay for prospective health care. Likewise, access to care must be extended to those currently without insurance to avoid creating a two-class system of prospective care haves and have-nots. Health care providers need to be educated about prospective care, and as mentioned above, the way doctors are reimbursed by insurers must change. Additionally, pharmaceutical research and regulation are in need of significant reform.<a style="mso-endnote-id:edn" href="#_edn12" name="_ednref" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[xii]</span></span></a> The last time politicians proposed such sweeping changes to health care was under the Clinton administration in 1993—and faced with strong opposition from many fronts, they were ultimately unsuccessful.<span class="MsoEndnoteReference"><span style="mso-special-character:footnote"><a style="mso-endnote-id:edn" href="#_edn13" name="_ednref" title="">[xiii]</a></span></span></p>
<p class="MsoNormal" align="center" style="text-align: left;"><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">Despite political challenges, making prospective health care available to all Americans is a critical part of curing our health care system. If the high rates of chronic disease are not directly addressed, we will continue to suffer from the current system’s inefficiencies and inadequacies. Nation-wide prospective health care has the potential to reduce chronic disease and make us healthier—even save our lives—while lowering the amount we spend on health care. We should settle for nothing less.</span></span></p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn1" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[i]</span></span></a> Donnelly, John. “47 million Americans are uninsured.” <u>The Boston Globe</u>. 29 August 2007. 23 March 2008 &lt;http://boston.com/news/nation/articles/2007/08/29/47_million_americans_are_uninsured/&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn2" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ii]</span></span></a> “Health Insurance Cost.” <u>National Coalition on Health Care</u>. 23 March 2008 &lt;http://www.nchc.org/facts/cost.shtml&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn3" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iii]</span></span></a> “Overweight and Obesity.” <u>Centers for Disease Control and Prevention</u>. 23 March 2008 &lt;http://www.cdc.gov/nccdphp/dnpa/obesity/index.htm&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn4" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[iv]</span></span></a> See 3.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoNormal" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn5" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[v]</span></span></a> Langheier, J. M., and R. Snyderman. &#8220;Prospective Medicine: The Role for Genomics in Personalized Health Planning.&#8221; Pharmacogenomics 5.1 (2004): 1-8.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoNormal" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn6" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vi]</span></span></a> Snyderman, R., and Z. Yoediono. &#8220;Prospective Care: A Personalized, Preventative Approach to Medicine.&#8221; Pharmacogenomics 7.1 (2006): 5-9.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn7" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[vii]</span></span></a> See 5.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn8" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[viii]</span></span></a> “Prospective Health Care.” <u>DukeMedNews</u>. 23 March 2008 &lt;http://dukemednews.org/mediakits/detail.php?id=7388&gt;.</p>
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<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn9" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[ix]</span></span></a> See 6.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoNormal" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn10" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[x]</span></span></a> Aspinall, M. G., and R. G. Hamermesh. &#8220;Realizing the Promise of Personalized Medicine.&#8221; Harv Bus Rev 85.10 (2007): 108-17, 65.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn11" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[xi]</span></span></a> “On the Issues: Straight Talk on Health System Reform.” <u>JohnMcCain.com</u>. 23 March 2008 &lt; http://www.johnmccain.com/Informing/Issues/19ba2f1c-c03f-4ac2-8cd5-5cf2edb527cf.htm&gt;.</p>
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.6in; text-indent: -0.5in;">“Plan for a Healthy America.” <u>BarackObama.com</u>. 23 March 2008 &lt;http://www.barackobama.com/issues/healthcare/&gt;.</p>
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.6in; text-indent: -0.5in;">“Providing Affordable and Accessible Health Care.” <u>HillaryClinton.com</u>. 23 March 2008 &lt;http://hillaryclinton.com/issues/healthcare/&gt;.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;margin-left: 0.5in; text-indent: -0.5in;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn12" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote">[xii]</span></span></a> See 10.</p>
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<div style="mso-element:endnote" id="edn">
<p class="MsoEndnoteText" style="text-align: left;"><a style="mso-endnote-id:edn" href="#_ednref" name="_edn13" title=""><span class="MsoEndnoteReference"><span style="mso-special-character: footnote">[xiii]</span></span></a> Priest, D., and M. Weisskopf. <u>The Washington Post</u> 11 October 1994, final ed.: a.06.</p>
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		<title>Independent Study Abstract: Recombination Signal Sequences</title>
		<link>http://blog.maxmasnick.com/independent-study-abstract-recombination-signal-sequences</link>
		<comments>http://blog.maxmasnick.com/independent-study-abstract-recombination-signal-sequences#comments</comments>
		<pubDate>Wed, 26 Dec 2007 07:24:59 +0000</pubDate>
		<dc:creator>Max</dc:creator>
		
		<category><![CDATA[Projects]]></category>

		<guid isPermaLink="false">http://blog.maxmasnick.com/independent-study-abstract-recombination-signal-sequences</guid>
		<description><![CDATA[The diversity of the antigen receptor repertoire in mammals and other jawed vertebrates is made possible primarily by V(D)J recombination, a genetic mechanism that rearranges V, D, and J gene segments to form antigen receptor genes encoding unique antigen binding regions. V(D)J recombination is mediated by regions flanking the V, D, and J segments called [...]]]></description>
			<content:encoded><![CDATA[<p>The diversity of the antigen receptor repertoire in mammals and other jawed vertebrates is made possible primarily by V(D)J recombination, a genetic mechanism that rearranges V, D, and J gene segments to form antigen receptor genes encoding unique antigen binding regions. V(D)J recombination is mediated by regions flanking the V, D, and J segments called recombination signal sequences (RSS), which include relatively well conserved 7- and 9-bp regions and a highly variable region of either 12- or 23-bp. Dr. Cowell et al. have developed a statistical method for detecting and predicting patterns of correlation between any number of nucleotides at any position in RSS, and have applied this method to a library of mouse RSS. Using this statistical method as a starting point, I will write a computer program to efficiently analyze RSS. I will then attempt to improve the model selection method used by Cowell et al., and test my new methods on the mouse RSS library and simulated data. I will then apply this method to analyze human RSS, and potentially RSS from other species as well, with the end goal of successful identification of RSS, prediction of their recombinogenic potential, and insight into their binding interactions with the V(D)J recombinase.<!--StartFragment-->
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